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Prince Edward Island has no law restricting puberty blockers, cross-sex hormones or surgeries for minors. Across Canada, Canadian Institute for Health Information data show double mastectomies on minors as young as 14. Prince Edward Island covers the cost through its public health plan.

National Post, 29 Sep 2023, reporting Canadian Institute for Health Information data

An adult born in Prince Edward Island who has lived there for at least three months can apply to change the gender designation. The application includes a personal statement and a medical practitioner's statement. The adult form lists male, female, and non-binary.

Government of Prince Edward Island — change of gender designation

A male who identifies as a woman can be housed in a women's federal prison, even if his body is male and his identification still says male, unless a health or safety problem cannot be resolved. A federal count of 99 gender-diverse prisoners, from December 2017 to March 2020, found that 62 percent were males who identify as women. At the end of that count, 67 percent of that group were still in men's prisons. Prince Edward Island has no federal women's prison. Women sentenced federally from Prince Edward Island go to Nova Institution for Women in Truro.

CSC Commissioner's Directive 100 (in effect 9 May 2022); CSC research report R-442